The visitors took the lead through Shahzod Ubaydullaev in the 33rd minute of the game at the Metallurg Stadium.
In the second-period injury minutes, Davron Isokov fired home again as Andijan side recorded a 2-0 win over the hosts in Bekabad.
Superleague Matchday 16
Stadium: "Metallurg" stadium, 2357 spectators
Referee: Asker Najafaliev