The hosts took an early lead through Otabek Haydarov in front of the home crowd just seven minutes after the kick-off.
After the restart, Muzaffar Muzaffarov and Zohid Abdullaev gave the lead for FC Metallurg before Bahrom Abdurahimov added the third in the 79th minute.
An 89-minute strike from Jahongir Ahmadov was not enough for the 10-man Kokand side to claim s single point.
Superleague Matchday 21
Stadium: Central stadium. Kokand, 3655 spectators
Referee: Ilgiz Tantashev