Bahodir Nasimov opened the scoring for the hosts in the 68th minute of the game before he registered a double with his second goal 9 minutes later.
Davron Isokov halved the deficit for Andijan side in the 79th minute by giving a hope for his side to level the scoring, but the score remained unchanged as Samarkand side advanced to the semifinals.
League Cup 1/4 final
Stadium: Dynamo stadium
Referee: Doston Rakhmanov