Igor Sergeev broke his goalless streak opening the scoring in the 53rd minute at the Pakhtakor Stadium.
In the 61st minute, Dragan Ceran converted a goal from a penalty spot before he increased the advantage for the hosts with his stunning goal just two minutes later.
Turkmenistan international Arslanmurat Amanov decreased the deficit for the reigning champions 17 minutes to complete.
Superleague Matchday 1
Stadium: Pakhtakor stadium
Referee: Sherzod Qosimov