Sayramjon Kholnazzarova gave an early lead for Tajikistan just 2 minutes after the kickoff at the National Stadium.
However, Iran cancelled out their lead through Fatemi Ghasemi in the 10th minute of the game, but teams went to the break with a 1-1 draw.
Samaneh Chakandi led Iran in front with her 51-minute goal before Fatemi Ghasemi added his second from a penalty kick.
Melika Motevali increased their advantage 3 minutes to complete as Iran earned a 4-1 come-back-from-behind victory.
CAFA Women’s Championship 2018 | Matchday Four
Tajikistan 1-4 Iran
Goals: Sayramjon Kholnazzarova (2) – Fatemi Ghasemi (10, 70), Samaneh Chakandi (51), Melika Motevali (87)