Goals from Javokhir Sidikov, Eldor Shomurodov and Jaloliddin Masharipov bagged all three points for the White Wolves at the Rashid Stadium.
Here are the key facts after the Central Asian derby between Turkmenistan and Uzbekistan.
Uzbekistan have won back-to-back matches in the Asian Cup for the first time since 2011; the last time they won their opening two matches of the competition.
This was the first time Turkmenistan have conceded more than three goals at the Asian Cup – they continue the search for their first ever win at the competition.
Uzbekistan have scored at least one goal in six of their last seven matches in the Asian Cup, only failing to score against Korea Republic in a 2-0 defeat in 2015.
This is only the second time Uzbekistan have scored four or more goals in an Asian Cup match – they scored five against Malaysia in 2007.
Uzbekistan is the first side to score four goals in the first half of an Asian Cup match since Bahrain put four past India in 2011.
Uzbekistan have kept just their second clean sheet in their last 11 matches in the Asian Cup.
Turkmenistan have failed to score for the second time in their five matches at the Asian Cup – the first time came against Uzbekistan in 2004.