The Swallows took the lead as Murodjon Toshmatov opened the scoring 20 minutes after the kickoff.
Shahzodbek Nurmatov doubled the lead for the hosts in the 38th minute and his side went to the break with a 2-0 lead at the interval.
FC Bunyodkor increased the advantage through Jovlon Ibrokhimov just 6 minutes after the second-period kick-off, while the visitors had no chance to claim a single point in Tashkent.
Superleague Matchday 23
Stadium: Bunyodkor, 4250 spectators
Referee: Temur Tukhtasinov