A 74-minute strike from Husniddin Gofurov secured a 1-0 win for the White Wolves in Qujing City, southwest China's Yunnan Province.
Central Asians will struggle with Myanmar on Thursday before they will face China on Saturday.
CFA Team China International Youth Football Tournament 2018
Uzbekistan 1-0 Tajikistan
Goal: Husniddin Gofurov (74)