Darko Stanoevich put Surkhon side into the lead in the 19th minute, while goals from Abdulaziz Yusupov in in either half ensured a 3-0 advantage for the visitors.
A 78-minute strike from Alisher Sanoev gave FC Kizilkum some hope, but the hosts never threatened an unlikely comeback.
Superleague Matchday 9
Stadium: "Yoshlik" stadium, 3254 spectators
Referee: Sherzod Qosimov